Reaction Details |
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Target | Plasmepsin II |
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Ligand | BDBM50273745 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_536036 (CHEMBL991606) |
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Ki | 21±n/a nM |
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Citation | Hidaka, K; Kimura, T; Ruben, AJ; Uemura, T; Kamiya, M; Kiso, A; Okamoto, T; Tsuchiya, Y; Hayashi, Y; Freire, E; Kiso, Y Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin. Bioorg Med Chem16:10049-60 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Plasmepsin II |
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Name: | Plasmepsin II |
Synonyms: | Aspartic hemoglobinase II | PFAPD | PLM2_PLAFX | PMII | Plasmepsin 2 | Plasmepsin 2 (PM-II) | Plasmepsin-II |
Type: | Enzyme |
Mol. Mass.: | 51482.09 |
Organism: | Plasmodium falciparum |
Description: | P46925 |
Residue: | 453 |
Sequence: | MDITVREHDFKHGFIKSNSTFDGLNIDNSKNKKKIQKGFQILYVLLFCSVMCGLFYYVYE
NVWLQRDNEMNEILKNSEHLTIGFKVENAHDRILKTIKTHKLKNYIKESVNFLNSGLTKT
NYLGSSNDNIELVDFQNIMFYGDAEVGDNQQPFTFILDTGSANLWVPSVKCTTAGCLTKH
LYDSSKSRTYEKDGTKVEMNYVSGTVSGFFSKDLVTVGNLSLPYKFIEVIDTNGFEPTYT
ASTFDGILGLGWKDLSIGSVDPIVVELKNQNKIENALFTFYLPVHDKHTGFLTIGGIEER
FYEGPLTYEKLNHDLYWQITLDAHVGNIMLEKANCIVDSGTSAITVPTDFLNKMLQNLDV
IKVPFLPFYVTLCNNSKLPTFEFTSENGKYTLEPEYYLQHIEDVGPGLCMLNIIGLDFPV
PTFILGDPFMRKYFTVFDYDNHSVGIALAKKNL
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BDBM50273745 |
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n/a |
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Name | BDBM50273745 |
Synonyms: | (R)-N-[(1S,2R)-2-Hydroxyindan-1-yl]-3-[(2S,3S)-3-(2,6-dimethyl-4-dimethylamino-phenoxyacetyl)amino-2-hydroxy-4-phenylbutanoyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxamide | CHEMBL504596 | KNI-10282 |
Type | Small organic molecule |
Emp. Form. | C37H46N4O6S |
Mol. Mass. | 674.849 |
SMILES | CN(C)c1cc(C)c(OCC(=O)N[C@@H](Cc2ccccc2)[C@H](O)C(=O)N2CSC(C)(C)[C@H]2C(=O)N[C@@H]2[C@H](O)Cc3ccccc23)c(C)c1 |r| |
Structure |
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