| Reaction Details |
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 | Report a problem with these data |
| Target | Peptidylglycine alpha-amidating monooxygenase |
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| Ligand | BDBM50273494 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_536305 (CHEMBL990739) |
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| IC50 | 35000±n/a nM |
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| Citation |  Merkler, DJ; Asser, AS; Baumgart, LE; Carballo, N; Carpenter, SE; Chew, GH; Cosner, CC; Dusi, J; Galloway, LC; Lowe, AB; Lowe, EW; King, L; Kendig, RD; Kline, PC; Malka, R; Merkler, KA; McIntyre, NR; Romero, M; Wilcox, BJ; Owen, TC Substituted hippurates and hippurate analogs as substrates and inhibitors of peptidylglycine alpha-hydroxylating monooxygenase (PHM). Bioorg Med Chem16:10061-74 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Peptidylglycine alpha-amidating monooxygenase |
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| Name: | Peptidylglycine alpha-amidating monooxygenase |
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| Synonyms: | AMD_RAT | Pam | Peptidyl-glycine alpha-amidating monooxygenase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 108665.78 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_536304 |
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| Residue: | 976 |
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| Sequence: | MAGRARSGLLLLLLGLLALQSSCLAFRSPLSVFKRFKETTRSFSNECLGTIGPVTPLDAS
DFALDIRMPGVTPKESDTYFCMSMRLPVDEEAFVIDFKPRASMDTVHHMLLFGCNMPSST
GSYWFCDEGTCTDKANILYAWARNAPPTRLPKGVGFRVGGETGSKYFVLQVHYGDISAFR
DNHKDCSGVSVHLTRVPQPLIAGMYLMMSVDTVIPPGEKVVNADISCQYKMYPMHVFAYR
VHTHHLGKVVSGYRVRNGQWTLIGRQNPQLPQAFYPVEHPVDVTFGDILAARCVFTGEGR
TEATHIGGTSSDEMCNLYIMYYMEAKYALSFMTCTKNVAPDMFRTIPAEANIPIPVKPDM
VMMHGHHKEAENKEKSALMQQPKQGEEEVLEQGDFYSLLSKLLGEREDVHVHKYNPTEKT
ESGSDLVAEIANVVQKKDLGRSDAREGAEHEEWGNAILVRDRIHRFHQLESTLRPAESRA
FSFQQPGEGPWEPEPSGDFHVEEELDWPGVYLLPGQVSGVALDSKNNLVIFHRGDHVWDG
NSFDSKFVYQQRGLGPIEEDTILVIDPNNAEILQSSGKNLFYLPHGLSIDTDGNYWVTDV
ALHQVFKLDPHSKEGPLLILGRSMQPGSDQNHFCQPTDVAVEPSTGAVFVSDGYCNSRIV
QFSPSGKFVTQWGEESSGSSPRPGQFSVPHSLALVPHLDQLCVADRENGRIQCFKTDTKE
FVREIKHASFGRNVFAISYIPGFLFAVNGKPYFGDQEPVQGFVMNFSSGEIIDVFKPVRK
HFDMPHDIVASEDGTVYIGDAHTNTVWKFTLTEKMEHRSVKKAGIEVQEIKEAEAVVEPK
VENKPTSSELQKMQEKQKLSTEPGSGVSVVLITTLLVIPVLVLLAIVMFIRWKKSRAFGD
HDRKLESSSGRVLGRFRGKGSGGLNLGNFFASRKGYSRKGFDRVSTEGSDQEKDEDDGTE
SEEEYSAPLPKPAPSS
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| BDBM50273494 |
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| n/a |
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| Name | BDBM50273494 |
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| Synonyms: | 6-O-Palmitoyl-L-ascorbate | CHEMBL457018 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H40O7 |
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| Mol. Mass. | 416.5488 |
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| SMILES | CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@@H]1OC(=O)C(O)C1O |r| |
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| Structure | 
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