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TargetSodium-dependent noradrenaline transporter
LigandBDBM50274918
Substrate/Competitorn/a
Meas. Tech.ChEMBL_493416
Ki 1±n/a nM
Citation Bannwart LMCarter DSCai HYChoy JCGreenhouse RJaime-Figueroa SIyer PSLin CJLee EKLucas MCLynch SMMadera AMMoore AOzboya KRaptova LRoetz RSchoenfeld RCStein KASteiner SVilla MWeikert RJZhai Y Novel 3,3-disubstituted pyrrolidines as selective triple serotonin/norepinephrine/dopamine reuptake inhibitors. Bioorg Med Chem Lett 18:6062-6 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium-dependent noradrenaline transporter
Name:Monoamine transporter
Synonyms:NET | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SLC6A2 | Serotonin Transporter (SERT) | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2
Type:Multi-pass membrane protein
Mol. Mass.:69337.72
Organism:Homo sapiens (Human)
Description:Competition binding assay was determined using hNET stably expressed in HEK293 cells.
Residue:617
Sequence:
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50274918
n/a
NameBDBM50274918
Synonyms:(+)-6-(3-benzylpyrrolidin-3-yl)-1H-indole | (-)-6-(3-benzylpyrrolidin-3-yl)-1H-indole | 6-(3-benzylpyrrolidin-3-yl)-1H-indole | CHEMBL459165
TypeSmall organic molecule
Emp. Form.C19H20N2
Mol. Mass.276.3755
SMILESC(c1ccccc1)C1(CCNC1)c1ccc2cc[nH]c2c1
Structure
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