| Reaction Details |
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 | Report a problem with these data |
| Target | Wee1-like protein kinase |
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| Ligand | BDBM50232242 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_522127 (CHEMBL1006579) |
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| IC50 | 26±n/a nM |
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| Citation |  Wichapong, K; Lindner, M; Pianwanit, S; Kokpol, S; Sippl, W Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors. Eur J Med Chem44:1383-95 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Wee1-like protein kinase |
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| Name: | Wee1-like protein kinase |
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| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71599.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1445054 |
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| Residue: | 646 |
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| Sequence: | MSFLSRQQPPPPRRAGAACTLRQKLIFSPCSDCEEEEEEEEEEGSGHSTGEDSAFQEPDS
PLPPARSPTEPGPERRRSPGPAPGSPGELEEDLLLPGACPGADEAGGGAEGDSWEEEGFG
SSSPVKSPAAPYFLGSSFSPVRCGGPGDASPRGCGARRAGEGRRSPRPDHPGTPPHKTFR
KLRLFDTPHTPKSLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTP
DSLLLHSSGQCRRRKRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFH
ELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHSHVV
RYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSM
SLVHMDIKPSNIFISRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDS
RFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWHEIRQGRLPRIPQVLSQ
EFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKK
AQMAKAAAEERALFTDRMATRSTTQSNRTSRLIGKKMNRSVSLTIY
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| BDBM50232242 |
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| n/a |
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| Name | BDBM50232242 |
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| Synonyms: | 4-(2-chlorophenyl)-8-(3-(dimethylamino)propoxy)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL272479 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22ClN3O4 |
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| Mol. Mass. | 463.913 |
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| SMILES | CN(C)CCCOc1cc2[nH]c3cc(c4C(=O)NC(=O)c4c3c2cc1O)-c1ccccc1Cl |
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| Structure | 
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