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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50279535 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_522127 (CHEMBL1006579) | ||
| IC50 | 64±n/a nM | ||
| Citation |  Wichapong, K; Lindner, M; Pianwanit, S; Kokpol, S; Sippl, W Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors. Eur J Med Chem44:1383-95 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50279535 | |||
| n/a | |||
| Name | BDBM50279535 | ||
| Synonyms: | 4-(2,6-dichlorophenyl)-9-hydroxy-6-(4-morpholino-4-oxobutyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL483611 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H23Cl2N3O5 | ||
| Mol. Mass. | 552.405 | ||
| SMILES | Oc1ccc2n(CCCC(=O)N3CCOCC3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(5.42,-7.62,;6.62,-8.58,;6.38,-10.11,;7.59,-11.07,;9.02,-10.51,;10.4,-11.21,;10.47,-12.75,;11.83,-13.46,;11.89,-15,;13.25,-15.72,;14.56,-14.9,;13.32,-17.26,;12.01,-18.07,;12.07,-19.6,;13.43,-20.32,;14.73,-19.5,;14.68,-17.96,;11.54,-10.18,;13.08,-10.21,;13.89,-8.88,;13.12,-7.53,;13.63,-6.08,;15.1,-5.63,;12.4,-5.15,;11.14,-6.03,;9.69,-5.52,;11.59,-7.5,;10.79,-8.82,;9.25,-8.98,;8.05,-8.02,;15.42,-8.9,;16.17,-10.25,;15.37,-11.57,;17.7,-10.27,;18.5,-8.95,;17.74,-7.6,;16.2,-7.58,;15.45,-6.24,)| | ||
| Structure | 
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