Reaction Details | |||
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Target | Wee1-like protein kinase | ||
Ligand | BDBM50279495 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_522127 (CHEMBL1006579) | ||
IC50 | 120±n/a nM | ||
Citation | Wichapong, K; Lindner, M; Pianwanit, S; Kokpol, S; Sippl, W Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors. Eur J Med Chem44:1383-95 (2009) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Wee1-like protein kinase | |||
Name: | Wee1-like protein kinase | ||
Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
Type: | PROTEIN | ||
Mol. Mass.: | 71599.12 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_1445054 | ||
Residue: | 646 | ||
Sequence: |
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BDBM50279495 | |||
n/a | |||
Name | BDBM50279495 | ||
Synonyms: | 6-(3-(1H-imidazol-1-yl)-3-oxopropyl)-4-(2,6-dichlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL486728 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H16Cl2N4O4 | ||
Mol. Mass. | 519.336 | ||
SMILES | Oc1ccc2n(CCC(=O)n3ccnc3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(13.54,.17,;14.74,-.8,;14.5,-2.33,;15.7,-3.29,;17.13,-2.74,;18.52,-3.44,;18.54,-4.98,;17.23,-5.77,;17.25,-7.31,;18.6,-8.06,;15.93,-8.11,;14.52,-7.51,;13.51,-8.67,;14.31,-9.99,;15.81,-9.65,;19.65,-2.41,;21.2,-2.44,;22,-1.12,;21.25,.24,;21.75,1.69,;23.23,2.13,;20.53,2.62,;19.27,1.74,;17.82,2.25,;19.71,.27,;18.91,-1.05,;17.37,-1.2,;16.17,-.24,;23.54,-1.15,;24.28,-2.5,;23.49,-3.81,;25.82,-2.53,;26.62,-1.2,;25.86,.15,;24.33,.17,;23.58,1.51,)| | ||
Structure |