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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Wee1-like protein kinase | ||
| Ligand | BDBM50279478 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_522127 (CHEMBL1006579) | ||
| IC50 | 110±n/a nM | ||
| Citation |  Wichapong, K; Lindner, M; Pianwanit, S; Kokpol, S; Sippl, W Receptor-based 3D-QSAR studies of checkpoint Wee1 kinase inhibitors. Eur J Med Chem44:1383-95 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Wee1-like protein kinase | |||
| Name: | Wee1-like protein kinase | ||
| Synonyms: | Serine/threonine-protein kinase WEE1 | WEE1 | WEE1 homolog (S. pombe) | WEE1_HUMAN | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 71599.12 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | ChEMBL_1445054 | ||
| Residue: | 646 | ||
| Sequence: |
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| BDBM50279478 | |||
| n/a | |||
| Name | BDBM50279478 | ||
| Synonyms: | 4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-morpholino-3-oxopropyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione | CHEMBL486101 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H21Cl2N3O5 | ||
| Mol. Mass. | 538.379 | ||
| SMILES | Oc1ccc2n(CCC(=O)N3CCOCC3)c3cc(c4C(=O)NC(=O)c4c3c2c1)-c1c(Cl)cccc1Cl |(-1.49,.05,;-.28,-.9,;-.49,-2.43,;.72,-3.38,;2.15,-2.8,;3.54,-3.48,;3.57,-5.02,;2.25,-5.81,;2.28,-7.35,;3.63,-8.09,;.96,-8.15,;-.38,-7.39,;-1.69,-8.18,;-1.67,-9.72,;-.32,-10.47,;1,-9.68,;4.66,-2.43,;6.21,-2.44,;6.99,-1.1,;6.21,.24,;6.7,1.7,;8.16,2.17,;5.46,2.61,;4.21,1.72,;2.75,2.2,;4.68,.25,;3.9,-1.08,;2.36,-1.26,;1.14,-.32,;8.52,-1.1,;9.29,-2.44,;8.52,-3.77,;10.83,-2.44,;11.6,-1.11,;10.83,.23,;9.29,.23,;8.52,1.56,)| | ||
| Structure | 
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