| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase-like 1 [2-358] |
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| Ligand | BDBM50246396 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_558916 (CHEMBL1022595) |
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| IC50 | 60±n/a nM |
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| Citation |  Jones, CD; Andrews, DM; Barker, AJ; Blades, K; Byth, KF; Finlay, MR; Geh, C; Green, CP; Johannsen, M; Walker, M; Weir, HM Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors. Bioorg Med Chem Lett18:6486-9 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase-like 1 [2-358] |
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| Name: | Cyclin-dependent kinase-like 1 [2-358] |
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| Synonyms: | CDKL1 | CDKL1_HUMAN | Cyclin-dependent kinase-like 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 41689.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774421 |
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| Residue: | 357 |
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| Sequence: | MEKYEKIGKIGEGSYGVVFKCRNRDTGQIVAIKKFLESEDDPVIKKIALREIRMLKQLKH
PNLVNLLEVFRRKRRLHLVFEYCDHTVLHELDRYQRGVPEHLVKSITWQTLQAVNFCHKH
NCIHRDVKPENILITKHSVIKLCDFGFARLLAGPSDYYTDYVATRWYRSPELLVGDTQYG
PPVDVWAIGCVFAELLSGVPLWPGKSDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKI
PDPEDMEPLELKFPNISYPALGLLKGCLHMDPTQRLTCEQLLHHPYFENIREIEDLAKEH
NKPTRKTLRKSRKHHCFTETSKLQYLPQLTGSSILPALDNKKYYCDTKKLNYRFPNI
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| BDBM50246396 |
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| n/a |
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| Name | BDBM50246396 |
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| Synonyms: | 2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)-N-methylbenzamide | CHEMBL455428 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21FN6O |
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| Mol. Mass. | 368.408 |
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| SMILES | CNC(=O)c1ccc(Nc2nccc(n2)-c2cnc(C)n2C(C)C)cc1F |
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| Structure | 
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