| Reaction Details |
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 | Report a problem with these data |
| Target | Activated CDC42 kinase 1 |
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| Ligand | BDBM50246260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559411 (CHEMBL1017265) |
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| Ki | 5±n/a nM |
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| Citation |  Kopecky, DJ; Hao, X; Chen, Y; Fu, J; Jiao, X; Jaen, JC; Cardozo, MG; Liu, J; Wang, Z; Walker, NP; Wesche, H; Li, S; Farrelly, E; Xiao, SH; Kayser, F Identification and optimization of N3,N6-diaryl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamines as a novel class of ACK1 inhibitors. Bioorg Med Chem Lett18:6352-6 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Activated CDC42 kinase 1 |
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| Name: | Activated CDC42 kinase 1 |
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| Synonyms: | ACK1 | ACK1_HUMAN | Activated CDC42 kinase 1 (ACK-1) | TNK2 | Tyrosine kinase non-receptor protein 2 |
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| Type: | Protein |
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| Mol. Mass.: | 114577.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q07912 |
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| Residue: | 1038 |
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| Sequence: | MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLW
EAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCL
IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNA
MHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGM
GYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPE
SLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDI
YNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRA
ENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPD
RIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKP
GLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLL
DETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVP
AGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQA
PAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPP
REPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRA
GPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTP
APAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPAD
KIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNL
EQAGCHLLGSWGPAHHKR
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| BDBM50246260 |
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| n/a |
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| Name | BDBM50246260 |
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| Synonyms: | CHEMBL487241 | N3-(2,6-dichlorophenyl)-1-(2-(dimethylamino)ethyl)-N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21Cl2N7 |
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| Mol. Mass. | 442.344 |
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| SMILES | CN(C)CCn1nc(Nc2c(Cl)cccc2Cl)c2cnc(Nc3ccccc3)nc12 |
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| Structure | 
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