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TargetCyclin-dependent kinase 1
LigandBDBM50246408
Substrate/Competitorn/a
Meas. Tech.ChEMBL_559443
IC50 2±n/a nM
Citation Jones CDAndrews DMBarker AJBlades KDaunt PEast SGeh CGraham MAJohnson KMLoddick SAMcFarland HMMcGregor AMoss LRudge DASimpson PBSwain MLTam KYTucker JAWalker M The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem Lett 18:6369-73 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 1
Name:Cyclin-dependent kinase 1/G1/S-specific cyclin-D1
Synonyms:Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | p34 protein kinase
Type:Enzyme Subunit
Mol. Mass.:34101.08
Organism:Homo sapiens (Human)
Description:P06493
Residue:297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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  Blast E-value cutoff:
BDBM50246408
n/a
NameBDBM50246408
Synonyms:(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)phenyl)((S)-3-(methylamino)pyrrolidin-1-yl)methanone | CHEMBL455657
TypeSmall organic molecule
Emp. Form.C23H28FN7O
Mol. Mass.437.5131
SMILESCN[C@H]1CCN(C1)C(=O)c1ccc(Nc2ncc(F)c(n2)-c2cnc(C)n2C(C)C)cc1 |r|
Structure
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