| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 2 |
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| Ligand | BDBM50246358 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559442 (CHEMBL1018123) |
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| IC50 | 18±n/a nM |
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| Citation |  Jones, CD; Andrews, DM; Barker, AJ; Blades, K; Daunt, P; East, S; Geh, C; Graham, MA; Johnson, KM; Loddick, SA; McFarland, HM; McGregor, A; Moss, L; Rudge, DA; Simpson, PB; Swain, ML; Tam, KY; Tucker, JA; Walker, M The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem Lett18:6369-73 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 2 |
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| Name: | Cyclin-dependent kinase 2 |
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| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33938.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P24941 |
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| Residue: | 298 |
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| Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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| BDBM50246358 |
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| n/a |
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| Name | BDBM50246358 |
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| Synonyms: | (4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone | CHEMBL451462 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H28FN7O |
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| Mol. Mass. | 437.5131 |
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| SMILES | CC(C)n1c(C)ncc1-c1nc(Nc2ccc(cc2)C(=O)N2CCN(C)CC2)ncc1F |
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| Structure | 
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