Reaction Details |
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Target | Cyclin-dependent kinase 2 |
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Ligand | BDBM50246407 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_559442 (CHEMBL1018123) |
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IC50 | 3±n/a nM |
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Citation | Jones, CD; Andrews, DM; Barker, AJ; Blades, K; Daunt, P; East, S; Geh, C; Graham, MA; Johnson, KM; Loddick, SA; McFarland, HM; McGregor, A; Moss, L; Rudge, DA; Simpson, PB; Swain, ML; Tam, KY; Tucker, JA; Walker, M The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem Lett18:6369-73 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2 |
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Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM50246407 |
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n/a |
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Name | BDBM50246407 |
Synonyms: | CHEMBL453629 | N-(2-(dimethylamino)ethyl)-2-fluoro-4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)benzamide |
Type | Small organic molecule |
Emp. Form. | C22H28FN7O |
Mol. Mass. | 425.5024 |
SMILES | CC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(C(=O)NCCN(C)C)c(F)c2)n1 |
Structure |
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