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TargetCyclin-dependent kinase 1
LigandBDBM50246359
Substrate/Competitorn/a
Meas. Tech.ChEMBL_559443 (CHEMBL1018124)
IC50 180±n/a nM
Citation Jones, CDAndrews, DMBarker, AJBlades, KDaunt, PEast, SGeh, CGraham, MAJohnson, KMLoddick, SAMcFarland, HMMcGregor, AMoss, LRudge, DASimpson, PBSwain, MLTam, KYTucker, JAWalker, M The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing. Bioorg Med Chem Lett18:6369-73 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 1
Name:Cyclin-dependent kinase 1
Synonyms:CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:Enzyme Subunit
Mol. Mass.:34101.08
Organism:Homo sapiens (Human)
Description:P06493
Residue:297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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  Blast E-value cutoff:
BDBM50246359
n/a
NameBDBM50246359
Synonyms:4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-ylamino)-N-(1-methylpiperidin-4-yl)benzamide | CHEMBL455468
TypeSmall organic molecule
Emp. Form.C24H31N7O
Mol. Mass.433.5492
SMILESCC(C)n1c(C)ncc1-c1ccnc(Nc2ccc(cc2)C(=O)NC2CCN(C)CC2)n1
Structure
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