| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50254461 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_560709 (CHEMBL1010844) |
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| Ki | 463±n/a nM |
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| Citation |  Cole, AG; Metzger, A; Brescia, MR; Qin, LY; Appell, KC; Brain, CT; Hallett, A; Ganju, P; Denholm, AA; Wareing, JR; Ritchie, TJ; Drake, GM; Bevan, SJ; MacGloinn, A; McBryde, A; Patel, V; Oakley, PJ; Nunez, X; Gstach, H; Schneider, P; Baldwin, JJ; Dolle, RE; McDonald, E; Henderson, I Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists. Bioorg Med Chem Lett19:119-22 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50254461 |
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| n/a |
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| Name | BDBM50254461 |
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| Synonyms: | CHEMBL507546 | N-(2-chlorobenzyl)-2-(N-(4-isobutoxy-3-methoxybenzyl)-4-(morpholinomethyl)phenylsulfonamido)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C32H40ClN3O6S |
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| Mol. Mass. | 630.195 |
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| SMILES | COc1cc(CN(CC(=O)NCc2ccccc2Cl)S(=O)(=O)c2ccc(CN3CCOCC3)cc2)ccc1OCC(C)C |
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| Structure | 
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