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TargetTumor necrosis factor receptor superfamily member 1A
LigandBDBM50255013
Substrate/Competitorn/a
Meas. Tech.ChEMBL_558470 (CHEMBL963876)
IC50 13000±n/a nM
Citation Tecle, HShao, JLi, YKothe, MKazmirski, SPenzotti, JDing, YHOhren, JMoshinsky, DColi, RJhawar, NBora, EJacques-O'Hagan, SWu, J Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg Med Chem Lett19:226-9 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tumor necrosis factor receptor superfamily member 1A
Name:Tumor necrosis factor receptor superfamily member 1A
Synonyms:CD_antigen=CD120a | TBPI | TNF-R1 | TNF-RI | TNFAR | TNFR-I | TNFR1 | TNFRSF1A | TNR1A_HUMAN | Tumor necrosis factor receptor R1 | Tumor necrosis factor receptor superfamily member 1A | Tumor necrosis factor receptor superfamily member 1A, membrane form | Tumor necrosis factor-binding protein 1 | p55 | p60
Type:PROTEIN
Mol. Mass.:50495.39
Organism:Homo sapiens (Human)
Description:ChEMBL_1509419
Residue:455
Sequence:
MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYIHPQNNSICCT
KCHKGTYLYNDCPGPGQDTDCRECESGSFTASENHLRHCLSCSKCRKEMGQVEISSCTVD
RDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECV
SCSNCKKSLECTKLCLPQIENVKGTEDSGTTVLLPLVIFFGLCLLSLLFIGLMYRYQRWK
SKLYSIVCGKSTPEKEGELEGTTTKPLAPNPSFSPTPGFTPTLGFSPVPSSTFTSSSTYT
PGDCPNFAAPRREVAPPYQGADPILATALASDPIPNPLQKWEDSAHKPQSLDTDDPATLY
AVVENVPPLRWKEFVRRLGLSDHEIDRLELQNGRCLREAQYSMLATWRRRTPRREATLEL
LGRVLRDMDLLGCLEDIEEALCGPAALPPAPSLLR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50255013
n/a
NameBDBM50255013
Synonyms:(S)-5-((2,4-diamino-4-oxobutanamido)methyl)-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)benzoic acid | CHEMBL517647
TypeSmall organic molecule
Emp. Form.C18H16F3IN4O4
Mol. Mass.536.2437
SMILESN[C@@H](CC(N)=O)C(=O)NCc1cc(C(O)=O)c(Nc2ccc(I)cc2F)c(F)c1F |r|
Structure
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