Reaction Details |
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Target | Serine/threonine-protein kinase 3 |
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Ligand | BDBM50255049 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_558472 (CHEMBL963878) |
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IC50 | >30000±n/a nM |
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Citation | Tecle, H; Shao, J; Li, Y; Kothe, M; Kazmirski, S; Penzotti, J; Ding, YH; Ohren, J; Moshinsky, D; Coli, R; Jhawar, N; Bora, E; Jacques-O'Hagan, S; Wu, J Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK? Bioorg Med Chem Lett19:226-9 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase 3 |
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Name: | Serine/threonine-protein kinase 3 |
Synonyms: | KRS1 | MST-2 | MST2 | Mammalian STE20-like protein kinase 2 | STE20-Like Kinase MST2 | STK3 | STK3_HUMAN | Serine/threonine-protein kinase 3 | Serine/threonine-protein kinase 3 (MST2) | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase Krs-1 | Serine/threonine-protein kinase MST2 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 56284.87 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 491 |
Sequence: | MEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQVPV
ESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIE
DEIATILKSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNT
VIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRAIFMIPTNPPPT
FRKPELWSDDFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIKAK
RHEEQQRELEEEEENSDEDELDSHTMVKTSVESVGTMRATSTMSEGAQTMIEHNSTMLES
DLGTMVINSEDEEEEDGTMKRNATSPQVQRPSFMDYFDKQDFKNKSHENCNQNMHEPFPM
SKNVFPDNWKVPQDGDFDFLKNLSLEELQMRLKALDPMMEREIEELRQRYTAKRQPILDA
MDAKKRRQQNF
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BDBM50255049 |
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n/a |
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Name | BDBM50255049 |
Synonyms: | 5-{[2-(4-Chloro-benzenesulfonyl)-acetyl]-hydrazonomethyl}-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzoic acid | CHEMBL481969 |
Type | Small organic molecule |
Emp. Form. | C22H14ClF3IN3O5S |
Mol. Mass. | 651.781 |
SMILES | OC(=O)c1cc(C=NNC(=O)CS(=O)(=O)c2ccc(Cl)cc2)c(F)c(F)c1Nc1ccc(I)cc1F |w:6.5| |
Structure |
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