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TargetProstaglandin E2 receptor EP3 subtype
LigandBDBM50255092
Substrate/Competitorn/a
Meas. Tech.ChEMBL_558516 (CHEMBL963082)
IC50 5.6±n/a nM
Citation Zhou, NZeller, WKrohn, MAnderson, HZhang, JOnua, EKiselyov, ASRamirez, JHalldorsdottir, GAndrésson, TGurney, MESingh, J 3,4-Disubstituted indole acylsulfonamides: a novel series of potent and selective human EP3 receptor antagonists. Bioorg Med Chem Lett19:123-6 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E2 receptor EP3 subtype
Name:Prostaglandin E2 receptor EP3 subtype
Synonyms:PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:Enzyme
Mol. Mass.:43335.03
Organism:Homo sapiens (Human)
Description:P43115
Residue:390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
RYHTNNYASSSTSLPCQCSSTLMWSDHLER
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BDBM50255092
n/a
NameBDBM50255092
Synonyms:2-(3-(2,4-dichlorophenylsulfonyl)-1H-indol-4-yloxy)-N-(4,5-dichlorothiophen-2-ylsulfonyl)acetamide | CHEMBL480609
TypeSmall organic molecule
Emp. Form.C20H12Cl4N2O6S3
Mol. Mass.614.326
SMILESClc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(c12)S(=O)(=O)c1ccc(Cl)cc1Cl
Structure
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