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TargetProstaglandin E2 receptor
LigandBDBM50254687
Substrate/Competitorn/a
Meas. Tech.ChEMBL_558515
IC50 9.7±n/a nM
Citation Zhou NZeller WKrohn MAnderson HZhang JOnua EKiselyov ASRamirez JHalldorsdottir GAndrésson TGurney MESingh J 3,4-Disubstituted indole acylsulfonamides: a novel series of potent and selective human EP3 receptor antagonists. Bioorg Med Chem Lett 19:123-6 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin E2 receptor
Name:Prostaglandin E2 receptor
Synonyms:PGE receptor, EP3 subtype | PGE2-R | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:Enzyme
Mol. Mass.:43335.03
Organism:Homo sapiens (Human)
Description:P43115
Residue:390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
RYHTNNYASSSTSLPCQCSSTLMWSDHLER
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  Blast E-value cutoff:
BDBM50254687
n/a
NameBDBM50254687
Synonyms:CHEMBL464032 | N-(4,5-dichlorothiophen-2-ylsulfonyl)-2-(3-(naphthalen-2-ylthio)-1H-indol-4-yloxy)acetamide
TypeSmall organic molecule
Emp. Form.C24H16Cl2N2O4S3
Mol. Mass.563.496
SMILESClc1cc(sc1Cl)S(=O)(=O)NC(=O)COc1cccc2[nH]cc(Sc3ccc4ccccc4c3)c12
Structure
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