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TargetMatriptase
LigandBDBM50253952
Substrate/Competitorn/a
Meas. Tech.ChEMBL_559006
Ki 0.08±n/a nM
Citation Steinmetzer TDönnecke DKorsonewski MNeuwirth CSteinmetzer PSchulze ASaupe SMSchweinitz A Modification of the N-terminal sulfonyl residue in 3-amidinophenylalanine-based matriptase inhibitors. Bioorg Med Chem Lett 19:67-73 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Matriptase
Name:Hepatocyte growth factor activator/Serine protease hepsin/Suppressor of tumorigenicity 14 protein
Synonyms:Epithin | MT-SP1 | Membrane-type serine protease 1 | Prostamin | ST14 | Serine protease TADG-15 | Suppressor of tumorigenicity 14 protein | Suppressor of tumorigenicity protein 14
Type:Single-pass type II membrane protein
Mol. Mass.:94769.23
Organism:Homo sapiens (Human)
Description:n/a
Residue:855
Sequence:
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
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  Blast E-value cutoff:
BDBM50253952
n/a
NameBDBM50253952
Synonyms:3-{(S)-3-[4-(2-Amino-ethyl)-piperidin-1-yl]-2-[3-(6-amino-2,3,4,5-tetrahydro-pyridin-3-yl)-benzenesulfonylamino]-3-oxo-propyl}-benzamidine | CHEMBL469090
TypeSmall organic molecule
Emp. Form.C28H39N7O3S
Mol. Mass.553.719
SMILESNCCC1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(N)=N)NS(=O)(=O)c1cccc(c1)C1CCC(N)=NC1 |r,c:39|
Structure
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