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TargetCaspase-8
LigandBDBM50273991
Substrate/Competitorn/a
Meas. Tech.ChEMBL_537869 (CHEMBL990681)
EC50>5000±n/a nM
Citation Smith, GGlaser, MPerumal, MNguyen, QDShan, BArstad, EAboagye, EO Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide. J Med Chem51:8057-67 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Caspase-8
Name:Caspase-8
Synonyms:Apoptotic cysteine protease | Apoptotic protease Mch-5 | CAP4 | CASP-8 | CASP8 | CASP8_HUMAN | Caspase | Caspase-8 subunit p10 | Caspase-8 subunit p18 | FADD-homologous ICE/CED-3-like protease | FADD-like ICE | FLICE | ICE-like apoptotic protease 5 | MACH | MCH5 | MORT1-associated CED-3 homolog
Type:Enzyme
Mol. Mass.:55373.89
Organism:Homo sapiens (Human)
Description:Q14790
Residue:479
Sequence:
MDFSRNLYDIGEQLDSEDLASLKFLSLDYIPQRKQEPIKDALMLFQRLQEKRMLEESNLS
FLKELLFRINRLDLLITYLNTRKEEMERELQTPGRAQISAYRVMLYQISEEVSRSELRSF
KFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILKRVCAQINKSLLKIINDYEE
FSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSESQTLDKVYQMKSKPRGYCLIIN
NHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQIYEILKIYQ
LMDHSNMDCFICCILSHGDKGIIYGTDGQEAPIYELTSQFTGLKCPSLAGKPKVFFIQAC
QGDNYQKGIPVETDSEEQPYLEMDLSSPQTRYIPDEADFLLGMATVNNCVSYRNPAEGTW
YIQSLCQSLRERCPRGDDILTILTEVNYEVSNKDDKKNMGKQMPQPTFTLRKKLVFPSD
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50273991
n/a
NameBDBM50273991
Synonyms:(S)-1-(4-Fluorobenzyl)-5-(2-(pyrimidin-4-yloxymethyl)-pyrrolidine-1-sulfonyl)isatin | CHEMBL515506
TypeSmall organic molecule
Emp. Form.C24H21FN4O5S
Mol. Mass.496.511
SMILESFc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N2CCC[C@H]2COc2ccncn2)cc1 |r|
Structure
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