Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM50233374 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_560895 (CHEMBL1013530) |
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IC50 | 5.6±n/a nM |
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Citation | Fang, L; Appenroth, D; Decker, M; Kiehntopf, M; Lupp, A; Peng, S; Fleck, C; Zhang, Y; Lehmann, J NO-donating tacrine hybrid compounds improve scopolamine-induced cognition impairment and show less hepatotoxicity. J Med Chem51:7666-9 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache |
Type: | Enzyme |
Mol. Mass.: | 71812.79 |
Organism: | Electrophorus electricus (Electric eel) |
Description: | n/a |
Residue: | 633 |
Sequence: | MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFA
EPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLY
LNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGF
LALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDS
RPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLI
DQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYG
APGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIV
GDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHR
ASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINV
DGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAE
RQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
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BDBM50233374 |
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n/a |
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Name | BDBM50233374 |
Synonyms: | 9-[N-gamma-(3'-(nitrooxy)propyl)-gamma-aminobutylamino]-1,2,3,4-tetrahydroacridine | CHEMBL407320 | N-(3-Nitrooxy-propyl)-N'-(1,2,3,4-tetrahydro-acridin-9-yl)-butane-1,4-diamine |
Type | Small organic molecule |
Emp. Form. | C20H28N4O3 |
Mol. Mass. | 372.4613 |
SMILES | [O-][N+](=O)OCCCNCCCCNc1c2CCCCc2nc2ccccc12 |
Structure |
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