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Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50273403
Substrate/Competitorn/a
Meas. Tech.ChEMBL_561232 (CHEMBL1012778)
Ki 110±n/a nM
Citation Fotsch, CBartberger, MDBercot, EAChen, MCupples, REmery, MFretland, JGuram, AHale, CHan, NHickman, DHungate, RWHayashi, MKomorowski, RLiu, QMatsumoto, GSt Jean, DJUrsu, SVéniant, MXu, GYe, QYuan, CZhang, JZhang, XTu, HWang, M Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. J Med Chem51:7953-67 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:Enzyme
Mol. Mass.:32409.16
Organism:Homo sapiens (Human)
Description:P28845
Residue:292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
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BDBM50273403
n/a
NameBDBM50273403
Synonyms:2-[(S)-1-(4-Chlorophenyl)ethylamino]-5-(3-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one | CHEMBL512731
TypeSmall organic molecule
Emp. Form.C15H19ClN2O2S
Mol. Mass.326.842
SMILESC[C@H](NC1=NC(=O)C(C)(S1)C(C)(C)O)c1ccc(Cl)cc1 |r,t:3|
Structure
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