Ki Summary

Reaction Details

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Target

Hydroxysteroid 11-beta dehydrogenase 1

Ligand

BDBM50273458

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_561242 (CHEMBL1013597)

12±n/a nM

Citation

Fotsch, C; Bartberger, MD; Bercot, EA; Chen, M; Cupples, R; Emery, M; Fretland, J; Guram, A; Hale, C; Han, N; Hickman, D; Hungate, RW; Hayashi, M; Komorowski, R; Liu, Q; Matsumoto, G; St Jean, DJ; Ursu, S; Véniant, M; Xu, G; Ye, Q; Yuan, C; Zhang, J; Zhang, X; Tu, H; Wang, M Further studies with the 2-amino-1,3-thiazol-4(5H)-one class of 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: reducing pregnane X receptor activity and exploring activity in a monkey pharmacodynamic model. J Med Chem51:7953-67 (2008) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Hydroxysteroid 11-beta dehydrogenase 1

Name:

Hydroxysteroid 11-beta dehydrogenase 1

Synonyms:

11-beta-hydroxysteroid dehydrogenase type 1

Type:

PROTEIN

Mol. Mass.:

32020.70

Organism:

Canis familiaris

Description:

ChEMBL_850498

Residue:

293

Sequence:

MAFKKKYLPPLLGFFLAYYYYSANEEFRPEMLQGKKVIVTGASKGIGEQMAYHLAKMGAH
VVVTARSKETLKKVVSHCLELGAASAHYIPGTMEDMTFAEQFVAKAGKLMGGLDMLILNH
ITNTSMNLFSGDIHLVRRSMEVNFLSYVVLSAAALPMLKQSNGSIVVVSSKAGKMSSPLV
APYSASKFALDGFFSSVRMEHSVTKVNVSITLCILGLINTDTAMKAVSGILSTVGASSKE
ECALEIIKGGALRQEEVYYDNSVWTAFLLGNPGRKILEFLSLRSYKLDKFINN

BDBM50273458

n/a

Name

BDBM50273458

Synonyms:

(5S)-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}-5-(1-hydroxy-1-methylethyl)-5-methyl-1,3-thiazol-4(5H)-one | (S)-2-[(S)-1-(4-Fluorophenyl)ethylamino]-5-(2-hydroxypropan-2-yl)-5-methylthiazol-4(5H)-one | CHEMBL455907

Type

Small organic molecule

Emp. Form.

C15H19FN2O2S

Mol. Mass.

310.387

SMILES

C[C@H](NC1=NC(=O)[C@@](C)(S1)C(C)(C)O)c1ccc(F)cc1 |r,t:3|

Structure