Reaction Details |
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Target | Mu-type opioid receptor |
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Ligand | BDBM50273464 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_561947 (CHEMBL1021465) |
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Ki | 7±n/a nM |
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Citation | Kurimura, M; Liu, H; Sulima, A; Hashimoto, A; Przybyl, AK; Ohshima, E; Kodato, S; Deschamps, JR; Dersch, CM; Rothman, RB; Lee, YS; Jacobson, AE; Rice, KC Probes for narcotic receptor mediated phenomena. 37. Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogues of the ortho- and para-d-isomers. J Med Chem51:7866-81 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Mu-type opioid receptor |
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Name: | Mu-type opioid receptor |
Synonyms: | M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44789.51 |
Organism: | Homo sapiens (Human) |
Description: | P35372 |
Residue: | 400 |
Sequence: | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
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BDBM50273464 |
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n/a |
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Name | BDBM50273464 |
Synonyms: | (1S,9S,10S)-11-(2-phenylethyl)-8-oxa-11-azatetracyclo[8.3.3.0^{1,9}.0^{2,7}]hexadeca-2(7),3,5-trien-6-ol | CHEMBL514724 |
Type | Small organic molecule |
Emp. Form. | C22H25NO2 |
Mol. Mass. | 335.4394 |
SMILES | Oc1cccc2c1O[C@@H]1[C@@H]3CCC[C@]21CCN3CCc1ccccc1 |r,THB:17:16:8:10.11.12| |
Structure |
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