| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelial lipase |
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| Ligand | BDBM50254343 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559992 (CHEMBL1018742) |
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| IC50 | 60±n/a nM |
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| Citation |  Goodman, KB; Bury, MJ; Cheung, M; Cichy-Knight, MA; Dowdell, SE; Dunn, AK; Lee, D; Lieby, JA; Moore, ML; Scherzer, DA; Sha, D; Suarez, DP; Murphy, DJ; Harpel, MR; Manas, ES; McNulty, DE; Annan, RS; Matico, RE; Schwartz, BK; Trill, JJ; Sweitzer, TD; Wang, DY; Keller, PM; Krawiec, JA; Jaye, MC Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett19:27-30 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelial lipase |
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| Name: | Endothelial lipase |
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| Synonyms: | EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG |
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| Type: | Protein |
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| Mol. Mass.: | 56805.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9Y5X9 |
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| Residue: | 500 |
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| Sequence: | MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
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| BDBM50254343 |
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| n/a |
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| Name | BDBM50254343 |
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| Synonyms: | (S)-1-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)-3-(1-phenylethyl)urea | CHEMBL467023 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H25N3O4S |
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| Mol. Mass. | 391.484 |
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| SMILES | C[C@H](NC(=O)Nc1cc(oc1C)S(=O)(=O)N1CCCCC1)c1ccccc1 |r| |
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| Structure | 
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