| Reaction Details |
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 | Report a problem with these data |
| Target | Lipoprotein lipase |
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| Ligand | BDBM50254433 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_559993 (CHEMBL1018743) |
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| IC50 | 500±n/a nM |
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| Citation |  Goodman, KB; Bury, MJ; Cheung, M; Cichy-Knight, MA; Dowdell, SE; Dunn, AK; Lee, D; Lieby, JA; Moore, ML; Scherzer, DA; Sha, D; Suarez, DP; Murphy, DJ; Harpel, MR; Manas, ES; McNulty, DE; Annan, RS; Matico, RE; Schwartz, BK; Trill, JJ; Sweitzer, TD; Wang, DY; Keller, PM; Krawiec, JA; Jaye, MC Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett19:27-30 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lipoprotein lipase |
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| Name: | Lipoprotein lipase |
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| Synonyms: | LIPL_RAT | Lpl |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53093.31 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_559993 |
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| Residue: | 474 |
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| Sequence: | MESKALLLVALGVWLQSLTAFRGGVAAADGGRDFSDIESKFALRTPEDTAEDTCHLIPGL
ADSVSNCHFNHSSKTFVVIHGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLYRAQQH
YPVSAGYTKLVGNDVARFINWLEEEFNYPLDNVHLLGYSLGAHAAGVAGSLTNKKVNRIT
GLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGHVDIYPNGGTFQ
PGCNIGEAIRVIAEKGLGDVDQLVKCSHERSIHLFIDSLLNEENPSKAYRCNSKEAFEKG
LCLSCRKNRCNNVGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKIHFSGTENDKQNNQ
AFEISLYGTVAESENIPFTLPEVATNKTYSFLIYTEVDIGELLMMKLKWKNDSYFRWSDW
WSSPSFVIEKIRVKAGETQKKVIFCAREKVSHLQKGKDAAVFVKCHDKSLKKSG
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| BDBM50254433 |
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| n/a |
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| Name | BDBM50254433 |
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| Synonyms: | 1-(2-methyl-5-(4-methylpiperazin-1-ylsulfonyl)furan-3-yl)-3-phenylurea | CHEMBL469114 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22N4O4S |
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| Mol. Mass. | 378.446 |
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| SMILES | CN1CCN(CC1)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2)c(C)o1 |
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| Structure | 
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