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TargetEndothelial lipase
LigandBDBM50254434
Substrate/Competitorn/a
Meas. Tech.ChEMBL_559992 (CHEMBL1018742)
IC50 250±n/a nM
Citation Goodman, KBBury, MJCheung, MCichy-Knight, MADowdell, SEDunn, AKLee, DLieby, JAMoore, MLScherzer, DASha, DSuarez, DPMurphy, DJHarpel, MRManas, ESMcNulty, DEAnnan, RSMatico, RESchwartz, BKTrill, JJSweitzer, TDWang, DYKeller, PMKrawiec, JAJaye, MC Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett19:27-30 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Endothelial lipase
Name:Endothelial lipase
Synonyms:EDL | EL | Endothelial cell-derived lipase | LIPE_HUMAN | LIPG
Type:Protein
Mol. Mass.:56805.62
Organism:Homo sapiens (Human)
Description:Q9Y5X9
Residue:500
Sequence:
MSNSVPLLCFWSLCYCFAAGSPVPFGPEGRLEDKLHKPKATQTEVKPSVRFNLRTSKDPE
HEGCYLSVGHSQPLEDCSFNMTAKTFFIIHGWTMSGIFENWLHKLVSALHTREKDANVVV
VDWLPLAHQLYTDAVNNTRVVGHSIARMLDWLQEKDDFSLGNVHLIGYSLGAHVAGYAGN
FVKGTVGRITGLDPAGPMFEGADIHKRLSPDDADFVDVLHTYTRSFGLSIGIQMPVGHID
IYPNGGDFQPGCGLNDVLGSIAYGTITEVVKCEHERAVHLFVDSLVNQDKPSFAFQCTDS
NRFKKGICLSCRKNRCNSIGYNAKKMRNKRNSKMYLKTRAGMPFRVYHYQMKIHVFSYKN
MGEIEPTFYVTLYGTNADSQTLPLEIVERIEQNATNTFLVYTEEDLGDLLKIQLTWEGAS
QSWYNLWKEFRSYLSQPRNPGRELNIRRIRVKSGETQRKLTFCTEDPENTSISPGRELWF
RKCRDGWRMKNETSPTVELP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50254434
n/a
NameBDBM50254434
Synonyms:5-Methyl-4-(3-phenyl-ureido)-furan-2-sulfonic acid (2-methoxy-ethyl)-methyl-amide | CHEMBL468281
TypeSmall organic molecule
Emp. Form.C16H21N3O5S
Mol. Mass.367.42
SMILESCOCCN(C)S(=O)(=O)c1cc(NC(=O)Nc2ccccc2)c(C)o1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: