| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50254126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_560038 (CHEMBL1021558) |
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| EC50 | >10000±n/a nM |
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| Citation |  Marx, IE; DiMauro, EF; Cheng, A; Emkey, R; Hitchcock, SA; Huang, L; Huang, MY; Human, J; Lee, JH; Li, X; Martin, MW; White, RD; Fremeau, RT; Patel, VF Discovery of alpha-amidosulfones as potent and selective agonists of CB2: synthesis, SAR, and pharmacokinetic properties. Bioorg Med Chem Lett19:31-5 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52868.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21554 |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50254126 |
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| n/a |
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| Name | BDBM50254126 |
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| Synonyms: | CHEMBL468275 | N-(4-chloro-2-(trifluoromethoxy)phenyl)-2-(4-chlorophenylsulfonyl)-2-methylpropanamide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14Cl2F3NO4S |
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| Mol. Mass. | 456.264 |
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| SMILES | CC(C)(C(=O)Nc1ccc(Cl)cc1OC(F)(F)F)S(=O)(=O)c1ccc(Cl)cc1 |
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| Structure | 
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