Reaction Details |
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Target | C-C chemokine receptor type 4 |
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Ligand | BDBM50243945 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_558790 (CHEMBL1020783) |
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IC50 | 18±n/a nM |
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Citation | Yokoyama, K; Ishikawa, N; Igarashi, S; Kawano, N; Masuda, N; Hamaguchi, W; Yamasaki, S; Koganemaru, Y; Hattori, K; Miyazaki, T; Ogino, S; Matsumoto, Y; Takeuchi, M; Ohta, M Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem17:64-73 (2008) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 4 |
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Name: | C-C chemokine receptor type 4 |
Synonyms: | C-C CKR-4 | C-C chemokine receptor type 4 | C-C chemokine receptor type 4 (CCR4) | CC-CKR-4 | CCR-4 | CCR4 | CCR4_HUMAN | CD_antigen=CD194 | CMKBR4 | K5-5 |
Type: | Enzyme |
Mol. Mass.: | 41406.41 |
Organism: | Homo sapiens (Human) |
Description: | P51679 |
Residue: | 360 |
Sequence: | MNPTDIADTTLDESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVV
VLVLFKYKRLRSMTDVYLLNLAISDLLFVFSLPFWGYYAADQWVFGLGLCKMISWMYLVG
FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT
ERNHTYCKTKYSLNSTTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKKNKA
VKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQATETLAFVHCCLN
PIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTPSSSYTQSTMDHDLHDAL
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BDBM50243945 |
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n/a |
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Name | BDBM50243945 |
Synonyms: | 2-(1,4'-Bipiperidine-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine | 2-(1,4'-bipiperidin-1'-yl)-N-cycloheptyl-6,7-dimethoxyquinazolin-4-amine | CHEMBL508207 | N-cycloheptyl-6,7-dimethoxy-2-(4-(piperidin-1-yl)piperidin-1-yl)quinazolin-4-amine |
Type | Small organic molecule |
Emp. Form. | C27H41N5O2 |
Mol. Mass. | 467.6467 |
SMILES | COc1cc2nc(nc(NC3CCCCCC3)c2cc1OC)N1CCC(CC1)N1CCCCC1 |
Structure |
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