| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50277148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_540418 (CHEMBL1029035) |
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| IC50 | 0.73±n/a nM |
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| Citation |  Evindar, G; Bernier, SG; Kavarana, MJ; Doyle, E; Lorusso, J; Kelley, MS; Halley, K; Hutchings, A; Wright, AD; Saha, AK; Hannig, G; Morgan, BA; Westlin, WF Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett19:369-72 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50277148 |
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| n/a |
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| Name | BDBM50277148 |
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| Synonyms: | (S)-2-amino-2-methyl-3-(4-(octyloxy)phenylamino)-3-oxopropyl dihydrogen phosphate | CHEMBL475495 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H31N2O6P |
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| Mol. Mass. | 402.4223 |
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| SMILES | CCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(O)(O)=O)cc1 |r| |
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| Structure | 
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