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TargetSphingosine 1-Phosphate Receptor 4
LigandBDBM50277149
Substrate/Competitorn/a
Meas. Tech.ChEMBL_540420
IC50 3.5±n/a nM
Citation Evindar GBernier SGKavarana MJDoyle ELorusso JKelley MSHalley KHutchings AWright ADSaha AKHannig GMorgan BAWestlin WF Synthesis and evaluation of alkoxy-phenylamides and alkoxy-phenylimidazoles as potent sphingosine-1-phosphate receptor subtype-1 agonists. Bioorg Med Chem Lett 19:369-72 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-Phosphate Receptor 4
Name:Sphingosine 1-phosphate receptor
Synonyms:EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41647.39
Organism:Homo sapiens (Human)
Description:n/a
Residue:384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLV
VLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFL
REGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLP
LLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRP
AARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNS
AVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDS
FRGSRSLSFRMREPLSSISSVRSI
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  Blast E-value cutoff:
BDBM50277149
n/a
NameBDBM50277149
Synonyms:(S)-2-amino-3-(3-fluoro-4-(octyloxy)phenylamino)-2-methyl-3-oxopropyl dihydrogen phosphate | CHEMBL515921
TypeSmall organic molecule
Emp. Form.C18H30FN2O6P
Mol. Mass.420.4128
SMILESCCCCCCCCOc1ccc(NC(=O)[C@@](C)(N)COP(O)(O)=O)cc1F |r|
Structure
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