Reaction Details |
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Target | Retinoic acid receptor RXR-gamma |
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Ligand | BDBM50218464 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_515111 (CHEMBL1024633) |
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IC50 | 380±n/a nM |
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Citation | Morishita, K; Yakushiji, N; Ohsawa, F; Takamatsu, K; Matsuura, N; Makishima, M; Kawahata, M; Yamaguchi, K; Tai, A; Sasaki, K; Kakuta, H Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity. Bioorg Med Chem Lett19:1001-3 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor RXR-gamma |
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Name: | Retinoic acid receptor RXR-gamma |
Synonyms: | NR2B3 | Nuclear receptor subfamily 2 group B member 3 | RXRG | RXRG_HUMAN | Retinoic acid receptor RXR-gamma | Retinoid X receptor gamma | Retinoid X receptor gamma/retinoic acid receptor alpha |
Type: | PROTEIN |
Mol. Mass.: | 50878.26 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_197216 |
Residue: | 463 |
Sequence: | MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERIL
EAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
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BDBM50218464 |
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n/a |
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Name | BDBM50218464 |
Synonyms: | (Z)-4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid | 4-(5,7,7,10,10-pentamethyl-2-nitro-7,8,9,10-tetrahydro-5H-5,13-diaza-benzo[4,5]cyclohepta[1,2-b]naphthalen-12-yl)-benzoic acid | CHEMBL326525 |
Type | Small organic molecule |
Emp. Form. | C29H29N3O4 |
Mol. Mass. | 483.5583 |
SMILES | CN1c2ccc(cc2N=C(c2ccc(cc2)C(O)=O)c2cc3c(cc12)C(C)(C)CCC3(C)C)[N+]([O-])=O |t:9| |
Structure |
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