Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50256750 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_519333 (CHEMBL947785) |
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IC50 | >30000±n/a nM |
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Citation | Lyne, PD; Aquila, B; Cook, DJ; Dakin, LA; Ezhuthachan, J; Ioannidis, S; Pontz, T; Su, M; Ye, Q; Zheng, X; Block, MH; Cowen, S; Deegan, TL; Lee, JW; Scott, DA; Custeau, D; Drew, L; Poondru, S; Shen, M; Wu, A Identification of amidoheteroaryls as potent inhibitors of mutant (V600E) B-Raf kinase with in vivo activity. Bioorg Med Chem Lett19:1026-9 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50256750 |
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n/a |
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Name | BDBM50256750 |
Synonyms: | CHEMBL475817 | N-(6-amino-5-chloropyridin-3-yl)-2-chloro-5-(3-(trifluoromethyl)benzamido)benzamide |
Type | Small organic molecule |
Emp. Form. | C20H13Cl2F3N4O2 |
Mol. Mass. | 469.244 |
SMILES | Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1Cl |
Structure |
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