| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonyl reductase [NADPH] 1 |
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| Ligand | BDBM8726 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_495288 (CHEMBL1004505) |
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| Ki | 60±n/a nM |
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| Citation |  Zimmermann, TJ; Niesen, FH; Pilka, ES; Knapp, S; Oppermann, U; Maier, ME Discovery of a potent and selective inhibitor for human carbonyl reductase 1 from propionate scanning applied to the macrolide zearalenone. Bioorg Med Chem17:530-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonyl reductase [NADPH] 1 |
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| Name: | Carbonyl reductase [NADPH] 1 |
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| Synonyms: | CBR | CBR1 | CBR1_HUMAN | CRN | SDR21C1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30380.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_607770 |
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| Residue: | 277 |
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| Sequence: | MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFH
QLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRD
VCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTK
KGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKA
TKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
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| BDBM8726 |
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| n/a |
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| Name | BDBM8726 |
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| Synonyms: | 5-chloro-2-(2,4-dichlorophenoxy)phenol | CHEMBL849 | TCL | Triclosan | US20230414581, Compound 35 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H7Cl3O2 |
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| Mol. Mass. | 289.542 |
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| SMILES | Oc1cc(Cl)ccc1Oc1ccc(Cl)cc1Cl |
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| Structure | 
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