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TargetSerine/threonine-protein kinase Chk1
LigandBDBM50256003
Substrate/Competitorn/a
Meas. Tech.ChEMBL_515217 (CHEMBL990372)
IC50 14±n/a nM
Citation Parmentier, JGPortevin, BGolsteyn, RMPierré, AHickman, JGloanec, PDe Nanteuil, G Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues. Bioorg Med Chem Lett19:841-4 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase Chk1
Name:Serine/threonine-protein kinase Chk1
Synonyms:CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:54443.02
Organism:Homo sapiens (Human)
Description:gi_166295192
Residue:476
Sequence:
MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50256003
n/a
NameBDBM50256003
Synonyms:4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]-1-bromo-4,6,7,9-tetrahydro-5H-3-thia-7,9-diaza-cyclopenta[a]azulen-8-one | CHEMBL507188
TypeSmall organic molecule
Emp. Form.C13H10BrN5O2S
Mol. Mass.380.22
SMILESNC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(Br)csc3c12 |w:3.2,t:1|
Structure
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