Reaction Details |
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Target | Serine/threonine-protein kinase Chk1 |
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Ligand | BDBM50256003 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_515217 (CHEMBL990372) |
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IC50 | 14±n/a nM |
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Citation | Parmentier, JG; Portevin, B; Golsteyn, RM; Pierré, A; Hickman, J; Gloanec, P; De Nanteuil, G Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues. Bioorg Med Chem Lett19:841-4 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Serine/threonine-protein kinase Chk1 |
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Name: | Serine/threonine-protein kinase Chk1 |
Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 54443.02 |
Organism: | Homo sapiens (Human) |
Description: | gi_166295192 |
Residue: | 476 |
Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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BDBM50256003 |
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n/a |
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Name | BDBM50256003 |
Synonyms: | 4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]-1-bromo-4,6,7,9-tetrahydro-5H-3-thia-7,9-diaza-cyclopenta[a]azulen-8-one | CHEMBL507188 |
Type | Small organic molecule |
Emp. Form. | C13H10BrN5O2S |
Mol. Mass. | 380.22 |
SMILES | NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(Br)csc3c12 |w:3.2,t:1| |
Structure |
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