| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
|---|
| Ligand | BDBM50256025 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_515217 (CHEMBL990372) |
|---|
| IC50 | 150±n/a nM |
|---|
| Citation |  Parmentier, JG; Portevin, B; Golsteyn, RM; Pierré, A; Hickman, J; Gloanec, P; De Nanteuil, G Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues. Bioorg Med Chem Lett19:841-4 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase Chk1 |
|---|
| Name: | Serine/threonine-protein kinase Chk1 |
|---|
| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 54443.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_166295192 |
|---|
| Residue: | 476 |
|---|
| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
|
|
|
|---|
| BDBM50256025 |
|---|
| n/a |
|---|
| Name | BDBM50256025 |
|---|
| Synonyms: | 4-[2-Amino-5-oxo-3,5-dihydro-imidazol-(4)-ylidene]-8-oxo-4,5,6,7,8,9-hexahydro-3-thia-7,9-diaza-cyclopenta[a]azulene-1-carboxylic acid amide | CHEMBL520929 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H12N6O3S |
|---|
| Mol. Mass. | 344.348 |
|---|
| SMILES | NC(=O)c1csc2c3c([nH]c12)C(=O)NCCC3=C1N=C(N)NC1=O |w:17.20,t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
