| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50256008 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_515217 (CHEMBL990372) |
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| IC50 | 260±n/a nM |
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| Citation |  Parmentier, JG; Portevin, B; Golsteyn, RM; Pierré, A; Hickman, J; Gloanec, P; De Nanteuil, G Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues. Bioorg Med Chem Lett19:841-4 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM50256008 |
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| n/a |
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| Name | BDBM50256008 |
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| Synonyms: | CHEMBL517241 | {5-[1-Bromo-8-oxo-6,7,8,9-tetrahydro-5H-3-thia-7,9-diaza-cyclopenta[a]azulen-(4)-ylidene]-4-oxo-4,5-dihydro-1H-imidazol-2-ylamino}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12BrN5O4S |
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| Mol. Mass. | 438.256 |
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| SMILES | OC(=O)CNC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3c(Br)csc3c12 |w:7.7,t:5| |
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| Structure | 
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