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TargetHistone deacetylase 1
LigandBDBM50255917
Substrate/Competitorn/a
Meas. Tech.ChEMBL_515326 (CHEMBL1035661)
IC50 90±n/a nM
Citation Raeppel, SZhou, NGaudette, FLeit, SPaquin, ILarouche, GMoradei, OFréchette, SIsakovic, LDelorme, DFournel, MKalita, ALu, ATrachy-Bourget, MCYan, PTLiu, JRahil, JWang, JBesterman, JMMurakami, KLi, ZVaisburg, A SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103). Bioorg Med Chem Lett19:644-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1
Name:Histone deacetylase 1
Synonyms:Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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  Blast E-value cutoff:
BDBM50255917
n/a
NameBDBM50255917
Synonyms:CHEMBL480923 | N-(2-aminophenyl)-4-((3-(pyridin-3-yl)phenylamino)methyl)benzamide
TypeSmall organic molecule
Emp. Form.C25H22N4O
Mol. Mass.394.4684
SMILESNc1ccccc1NC(=O)c1ccc(CNc2cccc(c2)-c2cccnc2)cc1
Structure
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