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TargetHistone deacetylase 1
LigandBDBM50255146
Substrate/Competitorn/a
Meas. Tech.ChEMBL_515326 (CHEMBL1035661)
IC50 250±n/a nM
Citation Raeppel, SZhou, NGaudette, FLeit, SPaquin, ILarouche, GMoradei, OFréchette, SIsakovic, LDelorme, DFournel, MKalita, ALu, ATrachy-Bourget, MCYan, PTLiu, JRahil, JWang, JBesterman, JMMurakami, KLi, ZVaisburg, A SAR and biological evaluation of analogues of a small molecule histone deacetylase inhibitor N-(2-aminophenyl)-4-((4-(pyridin-3-yl)pyrimidin-2-ylamino)methyl)benzamide (MGCD0103). Bioorg Med Chem Lett19:644-9 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1
Name:Histone deacetylase 1
Synonyms:Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50255146
n/a
NameBDBM50255146
Synonyms:CHEMBL482002 | N-(2-aminophenyl)-4-((2-(methylthio)-6-(pyridin-3-yl)pyrimidin-4-ylamino)methyl)benzamide
TypeSmall organic molecule
Emp. Form.C24H22N6OS
Mol. Mass.442.536
SMILESCSc1nc(NCc2ccc(cc2)C(=O)Nc2ccccc2N)cc(n1)-c1cccnc1
Structure
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