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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Transient receptor potential cation channel subfamily V member 1 | ||
| Ligand | BDBM50255382 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_515379 (CHEMBL1025534) | ||
| IC50 | 49±n/a nM | ||
| Citation |  Xiao, D; Palani, A; Aslanian, R; McKittrick, BA; McPhail, AT; Correll, CC; Phelps, PT; Anthes, JC; Rindgen, D Spiro-piperidine azetidinones as potent TRPV1 antagonists. Bioorg Med Chem Lett19:783-7 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Transient receptor potential cation channel subfamily V member 1 | |||
| Name: | Transient receptor potential cation channel subfamily V member 1 | ||
| Synonyms: | Capsaicin receptor | OTRPC1 | Osm-9-like TRP channel 1 | TRPV1 | TRPV1_HUMAN | Transient receptor potential cation channel subfamily V member 1 | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Transient receptor potential cation channel subfamily V member 1 (VR1/TRPV1) | Transient receptor potential cation channel subfamily V member 1(TRPV1) | VR1 | Vanilloid VR1 | Vanilloid receptor | Vanilloid receptor 1 | Vanilloid receptor 1 (TrpV1/Vr1) | Vanilloid receptor 1 (VRI/TRPV1) | ||
| Type: | Protein | ||
| Mol. Mass.: | 94960.75 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q8NER1 | ||
| Residue: | 839 | ||
| Sequence: |
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| BDBM50255382 | |||
| n/a | |||
| Name | BDBM50255382 | ||
| Synonyms: | (S)-N-((1r,4S)-4-tert-butylcyclohexyl)-1-oxo-2,3-diphenyl-2,7-diazaspiro[3.5]nonane-7-carboxamide | CHEMBL481609 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H39N3O2 | ||
| Mol. Mass. | 473.6496 | ||
| SMILES | CC(C)(C)[C@H]1CC[C@@H](CC1)NC(=O)N1CCC2(CC1)[C@@H](N(C2=O)c1ccccc1)c1ccccc1 |r,wU:4.3,19.32,wD:7.10,(30.29,-16.11,;28.97,-15.34,;28.2,-16.68,;29.75,-14.01,;27.63,-14.57,;26.3,-15.34,;24.97,-14.57,;24.97,-13.03,;26.3,-12.26,;27.63,-13.03,;23.64,-12.26,;22.31,-13.03,;22.31,-14.57,;20.97,-12.26,;19.65,-13.02,;18.32,-12.26,;18.31,-10.71,;19.65,-9.94,;20.97,-10.72,;17.54,-9.38,;16.2,-10.15,;16.98,-11.49,;16.58,-12.98,;14.71,-9.77,;14.31,-8.28,;12.83,-7.88,;11.74,-8.98,;12.15,-10.47,;13.63,-10.86,;17.93,-7.89,;19.42,-7.49,;19.81,-6,;18.72,-4.92,;17.23,-5.33,;16.84,-6.81,)| | ||
| Structure | 
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