| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor beta |
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| Ligand | BDBM50255198 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_515889 (CHEMBL993943) |
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| Ki | 7.1±n/a nM |
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| Citation |  Minutolo, F; Bertini, S; Granchi, C; Marchitiello, T; Prota, G; Rapposelli, S; Tuccinardi, T; Martinelli, A; Gunther, JR; Carlson, KE; Katzenellenbogen, JA; Macchia, M Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. J Med Chem52:858-67 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor beta |
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| Name: | Estrogen receptor beta |
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| Synonyms: | ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta |
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| Type: | Protein |
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| Mol. Mass.: | 59238.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92731 |
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| Residue: | 530 |
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| Sequence: | MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
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| BDBM50255198 |
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| n/a |
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| Name | BDBM50255198 |
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| Synonyms: | (E)-3-Chloro-4-(3-fluoro-4-hydroxyphenyl)salicylaldoxime | CHEMBL509051 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9ClFNO3 |
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| Mol. Mass. | 281.667 |
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| SMILES | Oc1ccc(cc1F)-c1ccc(CN=O)c(O)c1Cl |
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| Structure | 
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