| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A3 |
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| Ligand | BDBM50266416 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_516388 (CHEMBL988627) |
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| Ki | 19±n/a nM |
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| Citation |  Lanier, MC; Moorjani, M; Luo, Z; Chen, Y; Lin, E; Tellew, JE; Zhang, X; Williams, JP; Gross, RS; Lechner, SM; Markison, S; Joswig, T; Kargo, W; Piercey, J; Santos, M; Malany, S; Zhao, M; Petroski, R; Crespo, MI; Díaz, JL; Saunders, J; Wen, J; O'Brien, Z; Jalali, K; Madan, A; Slee, DH N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy. J Med Chem52:709-17 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A3 |
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| Name: | Adenosine receptor A3 |
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| Synonyms: | A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36197.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P0DMS8 |
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| Residue: | 318 |
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| Sequence: | MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE
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| BDBM50266416 |
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| n/a |
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| Name | BDBM50266416 |
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| Synonyms: | CHEMBL458224 | N-[2-(3,5-Dimethylpyrazol-1-yl)-6-(2-(R)-methoxymethylpyrrolidin-1-yl)pyrimidin-4-yl]acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C17H24N6O2 |
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| Mol. Mass. | 344.4115 |
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| SMILES | COC[C@H]1CCCN1c1cc(NC(C)=O)nc(n1)-n1nc(C)cc1C |r| |
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| Structure | 
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