| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50276260 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_540889 (CHEMBL1026563) |
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| IC50 | 1±n/a nM |
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| Citation |  Pryde, DC; Corless, M; Fenwick, DR; Mason, HJ; Stammen, BC; Stephenson, PT; Ellis, D; Bachelor, D; Gordon, D; Barber, CG; Wood, A; Middleton, DS; Blakemore, DC; Parsons, GC; Eastwood, R; Platts, MY; Statham, K; Paradowski, KA; Burt, C; Klute, W The design and discovery of novel amide CCR5 antagonists. Bioorg Med Chem Lett19:1084-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50276260 |
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| n/a |
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| Name | BDBM50276260 |
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| Synonyms: | (R)-N-benzyl-N-(1-(1-(2,6-dimethylbenzoyl)piperidin-4-yl)pyrrolidin-3-yl)cyclopropanecarboxamide | CHEMBL471623 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H37N3O2 |
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| Mol. Mass. | 459.623 |
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| SMILES | Cc1cccc(C)c1C(=O)N1CCC(CC1)N1CC[C@H](C1)N(Cc1ccccc1)C(=O)C1CC1 |r| |
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| Structure | 
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