Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50276444 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_540961 (CHEMBL1030681) |
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IC50 | 3887±n/a nM |
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Citation | Dockendorff, C; Jin, S; Olsen, M; Lautens, M; Coupal, M; Hodzic, L; Spear, N; Payza, K; Walpole, C; Tomaszewski, MJ Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions. Bioorg Med Chem Lett19:1228-32 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50276444 |
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n/a |
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Name | BDBM50276444 |
Synonyms: | (+/-)-2-(benzyloxy)-N-(2-methoxyethyl)-N-(2-(4-phenylpiperazin-1-yl)-1,2-dihydronaphthalen-1-yl)acetamide | CHEMBL459573 |
Type | Small organic molecule |
Emp. Form. | C32H37N3O3 |
Mol. Mass. | 511.6545 |
SMILES | COCCN(C1C(C=Cc2ccccc12)N1CCN(CC1)c1ccccc1)C(=O)COCc1ccccc1 |c:7| |
Structure |
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