| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mu-type opioid receptor |
|---|
| Ligand | BDBM50276624 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_540959 (CHEMBL1030679) |
|---|
| IC50 | 772±n/a nM |
|---|
| Citation |  Dockendorff, C; Jin, S; Olsen, M; Lautens, M; Coupal, M; Hodzic, L; Spear, N; Payza, K; Walpole, C; Tomaszewski, MJ Discovery of mu-opioid selective ligands derived from 1-aminotetralin scaffolds made via metal-catalyzed ring-opening reactions. Bioorg Med Chem Lett19:1228-32 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mu-type opioid receptor |
|---|
| Name: | Mu-type opioid receptor |
|---|
| Synonyms: | M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1 |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 44789.51 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P35372 |
|---|
| Residue: | 400 |
|---|
| Sequence: | MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP
PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT
STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF
RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI
FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI
YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI
EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
|
|
|
|---|
| BDBM50276624 |
|---|
| n/a |
|---|
| Name | BDBM50276624 |
|---|
| Synonyms: | (1R,2R)-N-(2-methoxyethyl)-2-(thiophen-3-yl)-1,2,3,4-tetrahydronaphthalen-1-amine | CHEMBL457247 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H21NOS |
|---|
| Mol. Mass. | 287.42 |
|---|
| SMILES | COCCN[C@@H]1[C@H](CCc2ccccc12)c1ccsc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
