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TargetHistone deacetylase 1
LigandBDBM50247927
Substrate/Competitorn/a
Meas. Tech.ChEMBL_543051 (CHEMBL1021292)
IC50 250±n/a nM
Citation Wang, HYu, NSong, HChen, DZou, YDeng, WLye, PLChang, JNg, MSun, ETSangthongpitag, KWang, XWu, XKhng, HHFang, LGoh, SKOng, WCBonday, ZStünkel, WPoulsen, AEntzeroth, M N-Hydroxy-1,2-disubstituted-1H-benzimidazol-5-yl acrylamides as novel histone deacetylase inhibitors: design, synthesis, SAR studies, and in vivo antitumor activity. Bioorg Med Chem Lett19:1403-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1
Name:Histone deacetylase 1
Synonyms:Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50247927
n/a
NameBDBM50247927
Synonyms:CHEMBL489706 | N-hydroxy-3-(2-phenethyl-1-(pyridin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)acrylamide | US10201527, Compound 16 | US10736881, Compound 16 | US8551988, 16
TypeSmall organic molecule
Emp. Form.C24H22N4O2
Mol. Mass.398.4571
SMILESONC(=O)\C=C\c1ccc2n(Cc3ccccn3)c(CCc3ccccc3)nc2c1
Structure
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