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TargetSodium- and chloride-dependent glycine transporter 1
LigandBDBM50248062
Substrate/Competitorn/a
Meas. Tech.ChEMBL_543461 (CHEMBL1016009)
IC50 2.9±n/a nM
Citation Wolkenberg, SEZhao, ZWisnoski, DDLeister, WHO'Brien, JLemaire, WWilliams, DLJacobson, MASur, CKinney, GGPettibone, DJTiller, PRSmith, SGibson, CMa, BKPolsky-Fisher, SLLindsley, CWHartman, GD Discovery of GlyT1 inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett19:1492-5 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium- and chloride-dependent glycine transporter 1
Name:Sodium- and chloride-dependent glycine transporter 1
Synonyms:GlyT-1 | GlyT1 | Glycine Transporters (GlyT1c) | Glycine transporter 1 | SC6A9_HUMAN | SLC6A9 | Sodium- and chloride-dependent glycine transporter 1 | Sodium- and chloride-dependent glycine transporter 1 (GlyT1) | Sodium- and chloride-dependent glycine transporter 1 (GlyT1c) | Sodium-and chloride-dependent glycine transporter 1 (GlyT-1c) | Solute carrier family 6 member 9
Type:Enzyme
Mol. Mass.:78270.54
Organism:Homo sapiens (Human)
Description:P48067
Residue:706
Sequence:
MSGGDTRAAIARPRMAAAHGPVAPSSPEQVTLLPVQRSFFLPPFSGATPSTSLAESVLKV
WHGAYNSGLLPQLMAQHSLAMAQNGAVPSEATKRDQNLKRGNWGNQIEFVLTSVGYAVGL
GNVWRFPYLCYRNGGGAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKG
VGYGMMVVSTYIGIYYNVVICIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNLTN
GSRPAALPSNLSHLLNHSLQRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLV
VFLCLIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKV
WGDAASQIFYSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGF
MANHLGVDVSRVADHGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETL
VTAIVDEVGNEWILQKKTYVTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVIS
CIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVSPAIIFFILVFTVIQYQPITY
NHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLKNATKPSRDWGPALLE
HRTGRYAPTIAPSPEDGFEVQPLHPDKAQIPIVGSNGSSRLQDSRI
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  Blast E-value cutoff:
BDBM50248062
n/a
NameBDBM50248062
Synonyms:2,4-dichloro-N-((1-(propylsulfonyl)-4-((tetrahydro-2H-pyran-2-yl)methyl)piperidin-4-yl)methyl)benzamide | CHEMBL518238
TypeSmall organic molecule
Emp. Form.C22H32Cl2N2O4S
Mol. Mass.491.471
SMILESCCCS(=O)(=O)N1CCC(CNC(=O)c2ccc(Cl)cc2Cl)(CC2CCCCO2)CC1
Structure
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