| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 1 |
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| Ligand | BDBM50279453 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_545265 (CHEMBL1020711) |
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| IC50 | 27±n/a nM |
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| Citation |  Du, L; Li, M; Yang, Q; Tang, Y; You, Q; Xia, L Molecular hybridization, synthesis, and biological evaluation of novel chroman I(Kr) and I(Ks) dual blockers. Bioorg Med Chem Lett19:1477-80 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 1 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 1 |
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| Synonyms: | IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1 | KCNQ1 | KCNQ1_CAVPO | KQT-like 1 | KVLQT1 | Potassium voltage-gated channel subfamily KQT member 1 | Voltage-gated potassium channel subunit Kv7.1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74450.11 |
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| Organism: | Cavia porcellus |
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| Description: | ChEMBL_88894 |
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| Residue: | 671 |
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| Sequence: | MAAASSPPRTERKRGGWGRLLGSRRGSASLAKKCPFSLELAEGGPAGGTLYAPVAPPGAL
SPGSPAPPASPAAPPAGLELGPRPPVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTG
WKCFVYHFAVFLIVLACLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAG
CRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRML
HVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSY
ADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQ
RQKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYVRKPARSHTLLSPSPKPKKSAMVR
KKKFKPDKDNGVSPGEKMLTVPHITCDPPEERRPDHFSVDGYDSSVRKSPTLLEVSPTHF
MRTNSFAEDLDLEGETLLTPITHVSQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVR
DVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKV
TQLDQRLVVITDMLHQLLSLHQGGPHSGGGPQMVQPCSEDGSIHPELFLPSNSLPTYEQL
TVPQRGPDEAS
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| BDBM50279453 |
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| n/a |
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| Name | BDBM50279453 |
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| Synonyms: | 1-(6-ethoxy-2,3-dihydrochromen-4-ylideneamino)-3-(3-(4-methylpiperazin-1-yl)propyl)imidazolidine-2,4-dione | CHEMBL487756 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H31N5O4 |
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| Mol. Mass. | 429.5126 |
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| SMILES | CCOc1ccc2OCCC(=Nn3cc(O)n(CCCN4CCN(C)CC4)c3=O)c2c1 |w:11.11| |
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| Structure | 
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