| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP3 subtype |
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| Ligand | BDBM50248277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_565894 (CHEMBL959317) |
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| IC50 | 2.6±n/a nM |
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| Citation |  Zhou, N; Zeller, W; Zhang, J; Onua, E; Kiselyov, AS; Ramirez, J; Palsdottir, G; Halldorsdottir, G; Andrésson, T; Gurney, ME; Singh, J 3-Acrylamide-4-aryloxyindoles: synthesis, biological evaluation and metabolic stability of potent and selective EP3 receptor antagonists. Bioorg Med Chem Lett19:1528-31 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP3 subtype |
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| Name: | Prostaglandin E2 receptor EP3 subtype |
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| Synonyms: | PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 43335.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43115 |
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| Residue: | 390 |
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| Sequence: | MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL
TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW
EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG
VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL
ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI
MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI
RYHTNNYASSSTSLPCQCSSTLMWSDHLER
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| BDBM50248277 |
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| n/a |
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| Name | BDBM50248277 |
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| Synonyms: | 3-(4-(3,4-dichlorophenoxy)-1-methyl-1H-indol-3-yl)-N-(2,4,5-trifluorophenylsulfonyl)acrylamide | CHEMBL475348 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H15Cl2F3N2O4S |
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| Mol. Mass. | 555.353 |
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| SMILES | Cn1cc(\C=C\C(=O)NS(=O)(=O)c2cc(F)c(F)cc2F)c2c(Oc3ccc(Cl)c(Cl)c3)cccc12 |
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| Structure | 
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