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TargetChemokine receptor type 1 (CXCR1)
LigandBDBM50247947
Substrate/Competitorn/a
Meas. Tech.ChEMBL_566227
Ki 52±n/a nM
Citation Biju PTaveras AGYu YZheng JHipkin RWFossetta JFan XFine JLundell D 3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists. Bioorg Med Chem Lett 19:1434-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Chemokine receptor type 1 (CXCR1)
Name:Interleukin-8 receptors, CXCR1/CXCR2
Synonyms:C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2
Type:Enzyme
Mol. Mass.:39803.83
Organism:Homo sapiens (Human)
Description:P25024
Residue:350
Sequence:
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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  Blast E-value cutoff:
BDBM50247947
n/a
NameBDBM50247947
Synonyms:(R)-3-(4-(1-(benzo[d][1,3]dioxol-5-yl)-2,2-dimethylpropylamino)-1,2,5-thiadiazol-3-ylamino)-2-hydroxy-N,N-dimethylbenzamide | CHEMBL522959
TypeSmall organic molecule
Emp. Form.C23H27N5O4S
Mol. Mass.469.557
SMILESCN(C)C(=O)c1cccc(Nc2nsnc2N[C@@H](c2ccc3OCOc3c2)C(C)(C)C)c1O |r|
Structure
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